Vol. 1 No. 1 (2025): Isotretinoin Immobilized on Silica/Ceria Nanoparticles for Optimized Topical Treatment of Acne Vulgaris

Abstract:
To treat acne more efficiently, we have synthesized ceria/silica nanoparticles with improved physicochemical
and biological properties to enhance topical delivery of isotretinoin. Two types of nanoparticles
were synthesized by the sol–gel and co-precipitation methodologies, namely silica containing
10% ceria (SC2 10%) and ceria (C2).