Current Issue
Vol. 1 No. 2 (2025): A Keratan Sulfate: An Electroconductive Proton Capture Glycosaminoglycan Regulator of Neuronal Membrane Polarization, Ion Fluxes, Neuronal Activation and Neurotransduction
ABSTRACT: This study describes keratan sulfate (KS), a multifunctional electroconductive glycosaminoglycan, and it’s participation in electrochemical processes that regulate neuronal activity. Neuronal cells are highly responsive to electrical stimulation and this is an intrinsic evolutionary property of this cell type.
Published:
2025-10-28
Full Issue
Welcome to the Global Open Access Journal of Science (GOAJS)
The Global Open Access Journal of Science (GOAJS) is an international, peer-reviewed platform dedicated to advancing scientific research across all disciplines. We are committed to removing barriers to knowledge, enabling global collaboration, and accelerating the dissemination of innovative research.
Broad Areas of Research We WelcomeWe invite original research, reviews, and scholarly articles from all major fields, including:
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- Engineering & Technology
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Our Mission
To provide a transparent, rigorous, and efficient peer-review process that ensures the rapid publication of high-quality scientific work for the benefit of the global research community.
Recent Articles
Open Access Review Physics
Refreshing the Theory of Relativity: Promoting an Interdisciplinary Dialog on Space, Time and Movement
Bernard GUY*
Abstract Views: 06 ⬇ Downloads: 11 DOI: 10.212333/goajs.v1i1.1011
Abstract: The theory of relativity must be reworked. Quite simply because it does not properly address the question of time. It avoids confronting it, taking its object for granted, hidden as it is in punctual clocks that don’t exist. However, it’s not a question of getting rid of it, nor fundamentally modifying its mathematical formalism....
Open Access Review Biology
Charles Darwin Revisited through the Lens of FIKR (Facet, Insight, Knowledge, and Resilience): Reflections on Curiosity, Compassion, and the Intellect as Foundations of Scientific Discovery
Chee Kong Yap1*
Chee Seng Leow2, and Wing Sum Vincent Leong2*
Chee Seng Leow2, and Wing Sum Vincent Leong2*Abstract Views: 06 ⬇ Downloads: 11 DOI: 10.212333/goajs.v1i1.1012
Abstract: In addition to his theory of evolution, Charles Darwin (CD) left behind insightful teachings about how Curiosity, Compassion, and Intellect (CCI) define both scientific brilliance and the human condition. In order to identify the fundamental principles that drove CD’s revolutionary contributions, this review reexamines his life, character, family, and educational background within the framework of the FIKR (Facet, Insight, Knowledge, and Resilience) model....
Open Access Research Physics
Discharge Structure of Ar/SF6 Inductively Coupled Plasma at High Pressure
Shu-Xia Zhao*
*
*Abstract Views: 03 ⬇ Downloads: 6 DOI: 10.212333/goajs.v1i1.1013
Abstract: In the article, the discharge structure of Ar/SF6 inductively coupled plasma at high pressure is studied. At high electronegativity, the island potential is formed at discharge initial stage, and most of plasma dynamics are occurred in the potential. The self-coagulation and diffusion of both ambi-polar type exist in the plasma.....
Open Access Research Nanotechnology
Isotretinoin Immobilized on Silica/Ceria Nanoparticles for Optimized Topical Treatment of Acne VulgarisCaroline Borges Azevedo1, Mario Ferreira Conceição Santos1, Michelle Saltarelli1, Wilson Rodrigues Braz* , Arthur Barcelos Ribeiro1, Mariana Brentini Santiago2, Anna Lívia Oliveira Santos2, Emerson Henrique de Faria1, Eduardo Ferreira Molina1, Lucas Alonso Rocha1, Denise Crispim Tavares Barbosa1, Carlos Henrique Gomes Martins2, Renata Fonseca Vianna Lopez3, and Eduardo José Nassar1
, Arthur Barcelos Ribeiro1, Mariana Brentini Santiago2, Anna Lívia Oliveira Santos2, Emerson Henrique de Faria1, Eduardo Ferreira Molina1, Lucas Alonso Rocha1, Denise Crispim Tavares Barbosa1, Carlos Henrique Gomes Martins2, Renata Fonseca Vianna Lopez3, and Eduardo José Nassar1 Abstract Views:55 ⬇ Downloads:31 | DOI: 10.212333/goajs.v1i1.1012
Abstract: To treat acne more efficiently, we have synthesized ceria/silica nanoparticles with improved physicochemical and biological properties to enhance topical delivery of isotretinoin. Two types of nanoparticles were synthesized by the sol–gel and co-precipitation methodologies, namely silica containing 10% ceria (SC2 10%) and ceria (C2)...
Open Access ResearchPhysics
Discharge Structure of Ar/SF6 Inductively Coupled Plasma at Relatively Low PressuresShu-Xia Zhao*
Abstract Views: 06 ⬇ Downloads: 11 DOI: 10.212333/goajs.v1i1.1011
Abstract: The discharge structure in an electronegative Ar/SF6 inductively coupled plasma is investigated in the article at low pressure, 10mTorr. Parabola profile in the electronegative plasma core is given by the fluid simulation, in accordance to the prediction of analytical theory....
Open Access Research Materials Science
Possibility of Phase Transition in Mechanical MetamaterialsJulian Plewa*
Abstract Views: 06 ⬇ Downloads: 11 DOI: 10.212333/goajs.v1i1.1011
Abstract: Based on the available knowledge from numerous simulation studies regarding the occurrence of metamaterial phase transition, structures were produced that exhibit a real auxetic-non-auxetic transition. The occurrence of this transition was possible thanks to the modified structure of rotating rectangles, showing significant dimensional changes....
Open Access Review Proteomics
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Abstract Views: 06 ⬇ Downloads: 11
Abstract: Nowadays, single-cell proteomics emerges and applied for some critical realm both scientifically and medically. In single-cell analysis, biological variability can be attributed to individual cells, their specific state, and the ability to respond to external stimuli, which are determined by protein abundance and their relative alterations.....
Open Access Review Neurology
A Keratan Sulfate: An Electroconductive Proton Capture Glycosaminoglycan Regulator of Neuronal Membrane Polarization, Ion Fluxes, Neuronal Activation and NeurotransductionJames Melrose1,2*
Abstract Views: 02 ⬇ Downloads: 05
Abstract: This study describes keratan sulfate (KS), a multifunctional electroconductive glycosaminoglycan, and it’s participation in electrochemical processes that regulate neuronal activity. Neuronal cells are highly responsive to electrical stimulation and this is an intrinsic evolutionary property of this cell type.....
