Archives

• Humanization of Laboratory Mice for HIV Research: Current Methods and Perspectives

  Vol. 1 No. 3 (2025)

  Relevance of the Topic
  Studying the pathogenesis of HIV infection and developing novel therapeutic strategies require adequate preclinical
  models that replicate key aspects of viral interaction with the human immune system. Traditional models,
  such as primates or transgenic animals, face significant limitations, including high costs, ethical concerns,
  and insufficient accuracy in mimicking human immune responses (Dash PK et al., 2021, Bennett MS, Akkina R,
  2013). In this context, humanized mice, created by transplanting human hematopoietic stem cells (HSCs) or tissues
  into immunodeficient mice, have emerged as revolutionary tools. These models enable the study of HIV
  infection in vivo, including latent reservoirs, immune responses, and the efficacy of antiretroviral therapy (ART)
  (Zhang C et al., 2023, Baroncini L et al., 2023).

• Possibility of Phase Transition in Mechanical Metamaterials

  Vol. 1 No. 2 (2025)

  Based on the available knowledge from numerous simulation studies regarding the occurrence of
  metamaterial phase transition, structures were produced that exhibit a real auxetic-non-auxetic transition.
  The occurrence of this transition was possible thanks to the modified structure of rotating
  rectangles, showing significant dimensional changes.

• Refreshing the Theory of Relativity: Promoting an Interdisciplinary Dialog on Space, Time and Movement

  Vol. 1 No. `1 (2025)

  Abstract:
  The theory of relativity must be reworked. Quite simply because it does not properly address the
  question of time. It avoids confronting it, taking its object for granted, hidden as it is in punctual
  clocks that don’t exist. However, it’s not a question of getting rid of it, nor fundamentally modifying
  its mathematical formalism. We should even consider it as expressing the general structure of
  our understanding of space and time, extending beyond the realm of physics and into the human
  and social sciences. It points the way to a close relationship between time and space. 

• Socio-economic Impacts of Ecosystem Service Degradation in Southern Ecological Zone of Taraba State Nigeria

  Vol. 1 No. 3 (2025)

  The degradation of ecosystem services poses a critical threat to rural livelihoods and socio-economic stability
  in resource-dependent regions of sub-Saharan Africa. This study investigates the perceived socio-economic
  impacts of ecosystem service decline across five Local Government Areas (LGAs); Bali, Gashaka, Sardauna, Takum,
  and Ussa—in the Southern Ecological Zone of Taraba State, Nigeria. Employing a mixed-methods approach,
  data were collected from 450 randomly sampled households using a structured questionnaire with a 5-point
  Likert scale, complemented by 15 key informant interviews. Descriptive statistics, one-way ANOVA, and thematic
  analysis were utilized to analyze the data. Findings reveal a hierarchy of perceived impacts, with declining
  community well-being ranked as the most severe (Mean = 3.69), followed by disproportionate impacts on
  women (Mean = 2.10) and heightened youth unemployment (Mean = 2.09).

• A Keratan Sulfate: An Electroconductive Proton Capture Glycosaminoglycan Regulator of Neuronal Membrane Polarization, Ion Fluxes, Neuronal Activation and Neurotransduction

  Vol. 1 No. 2 (2025)

  ABSTRACT: This study describes keratan sulfate (KS), a multifunctional electroconductive glycosaminoglycan, and it’s participation in electrochemical processes that regulate neuronal activity. Neuronal cells are highly responsive to electrical stimulation and this is an intrinsic evolutionary property of this cell type.

• Charles Darwin Revisited through the Lens of FIKR (Facet, Insight, Knowledge, and Resilience): Reflections on Curiosity, Compassion, and the Intellect as Foundations of Scientific Discovery

  Vol. 1 No. 1 (2025)

  In addition to his theory of evolution, Charles Darwin (CD) left behind insightful teachings about
  how Curiosity, Compassion, and Intellect (CCI) define both scientific brilliance and the human condition.
  In order to identify the fundamental principles that drove CD’s revolutionary contributions,
  this review reexamines his life, character, family, and educational background within the framework
  of the FIKR (Facet, Insight, Knowledge, and Resilience) model.

• Immunohistochemical Expression of MSH2 and MLH1 and Their Correlation with Histological Grades of Colorectal Carcinoma at Uganda Cancer Institute

  Vol. 1 No. 3 (2025)

  Background: Colorectal Cancer (CRC) is a rising health challenge in Uganda. The mismatch repair (MMR) system,
  particularly MSH2 and MLH1, plays a critical role in maintaining genomic stability; defects contribute to
  CRC development. Immunohistochemistry (IHC) is a cost-effective method for detecting MMR protein expression
  in CRC tissues and aids diagnosis and treatment.
  Study design

• Discharge Structure of Ar/SF6 Inductively Coupled Plasma at Relatively Low Pressures

  Vol. 1 No. 1 (2025)

  The discharge structure in an electronegative Ar/SF6 inductively coupled plasma is investigated in
  the article at low pressure, 10mTorr. Parabola profile in the electronegative plasma core is given by
  the fluid simulation, in accordance to the prediction of analytical theory. Except the ordinary sheath,
  the overall discharge is separated into the electronegative core and electropositive edge, which are
  connected by a dielectric-type double layer.

• Lactylation: A Pivotal Metabolic-Epigenetic Nexus Driving Hepatocellular Carcinoma Pathogenesis and Therapeutic Resistance

  Vol. 1 No. 3 (2025)

  Hepatocellular Carcinoma (HCC) remains a formidable global health challenge, characterized by its complex
  etiology, aggressive progression, and high mortality rates. Metabolic reprogramming is a hallmark of cancer,
  and lactate, a key end-product of glycolysis, has emerged as more than just a metabolic waste product. Recent
  groundbreaking research has unveiled lactate’s role as a signaling molecule through a novel Post-Translational
  Modification (PTM) known as lactylation. Protein lactylation, particularly histone lactylation, directly links cellular
  metabolism to epigenetic regulation, profoundly influencing gene expression, protein function, and cellular
  phenotypes. In the context of HCC, an increasing body of evidence highlights the widespread and critical
  involvement of lactylation in various pathological processes, including tumor initiation, progression, metastasis,
  immune evasion, and therapeutic resistance. This comprehensive review synthesizes the current understanding
  of protein lactylation in HCC, detailing its intricate mechanisms, diverse functional roles in metabolic

• Advances in Single-cell Proteomics

  Vol. 1 No. 2 (2025)

  Abstract: Nowadays, single-cell proteomics emerges and applied for some critical realm both scientifically
  and medically. In single-cell analysis, biological variability can be attributed to individual cells,
  their specific state, and the ability to respond to external stimuli, which are determined by protein
  abundance and their relative alterations.

• Isotretinoin Immobilized on Silica/Ceria Nanoparticles for Optimized Topical Treatment of Acne Vulgaris

  Vol. 1 No. 1 (2025)

  Abstract:
  To treat acne more efficiently, we have synthesized ceria/silica nanoparticles with improved physicochemical
  and biological properties to enhance topical delivery of isotretinoin. Two types of nanoparticles
  were synthesized by the sol–gel and co-precipitation methodologies, namely silica containing
  10% ceria (SC2 10%) and ceria (C2). 

• Nikethamide Alleviates Low SpO2 during Gastrointestinal Endoscopy under Total Intravenous Anesthesia with Propofol Combined with Sufentanil: A Randomized Controlled Trial

  Vol. 1 No. 2 (2025)

  ABSTRACT
  Background: Gastrointestinal Endoscopy under Total Intravenous Anesthesia (GETIVA) is used for gastroin- testinal disease investigation. Total intravenous anesthesia with propofol and opioids is usually applied but could result in respiratory depression or low oxygen saturation. This study aimed to test the effectiveness of nikethamide (respiratory stimulant) for alleviating low oxygen saturation induced by combined propofol and sufentanil use during GETIVA.

• Discharge structure of Ar/SF6 inductively coupled plasma at high pressure

  Vol. 1 No. 1 (2025)

  In the article, the discharge structure of Ar/SF6 inductively coupled plasma at high pressure is studied.
  At high electronegativity, the island potential is formed at discharge initial stage, and most of
  plasma dynamics are occurred in the potential. The self-coagulation and diffusion of both ambi-polar
  type exist in the plasma. The plasma is torn by the competition of them and a blue sheath is appeared
  in plasma.