Vol. 1 No. 3 (2025): Immunohistochemical Expression of MSH2 and MLH1 and Their Correlation with Histological Grades of Colorectal Carcinoma at Uganda Cancer Institute

Background: Colorectal Cancer (CRC) is a rising health challenge in Uganda. The mismatch repair (MMR) system,
particularly MSH2 and MLH1, plays a critical role in maintaining genomic stability; defects contribute to
CRC development. Immunohistochemistry (IHC) is a cost-effective method for detecting MMR protein expression
in CRC tissues and aids diagnosis and treatment.
Study design