Open Access
Volume 1 : Issue 3
Research Article
Oncology
Mutale Geoffrey, Wasswa Hassan, Amadile Lawrence, Nuwashaba Nicholas, Atwine Raymond, Ssedyabane Frank
Dec 03, 2025
Article Views: 605
Download: 459
Pages: 156-163
DOI Pending
Abstract: Immunohistochemical Expression of MSH2 and MLH1 and Their Correlation with Histological Grades of Colorectal Carcinoma at Uganda Cancer Institute, Background: Colorectal Cancer (CRC) is a rising health challenge in Uganda. The mismatch repair (MMR) system, particularly MSH2 and MLH1, plays a critical role in maintaining genomic stability; defects contribute to CRC development. Immunohistochemistry (IHC) is a cost-effective method for detecting MMR protein expression in CRC tissues and aids diagnosis and treatmen... Read more
Open Access
Volume 1 : Issue 3
Review Article
Immunology
Author details will be updated soon.
Dec 10, 2025
Article Views: 590
Download: 525
Pages: 164-178
DOI Pending
Abstract: Humanization of Laboratory Mice for HIV Research: Current Methods and Perspectives, Relevance of the Topic Studying the pathogenesis of HIV infection and developing novel therapeutic strategies require adequate preclinical models that replicate key aspects of viral interaction with the human immune system. Traditional models, such as primates or transgenic animals, face significant limitations, including high costs, ethical concerns, and insufficient accuracy in mimicking human immune responses (Dash PK et al.,... Read more
Open Access
Volume 1 : Issue 3
Review Article
Cancer
Dengwang Chen, Xinyue Jiang, Linna Wei, Zudi Meng, Dongmei Li
Dec 20, 2025
Article Views: 623
Download: 555
Pages: 179-191
DOI Pending
Abstract: Lactylation: A Pivotal Metabolic-Epigenetic Nexus Driving Hepatocellular Carcinoma Pathogenesis and Therapeutic Resistance, Hepatocellular Carcinoma (HCC) remains a formidable global health challenge, characterized by its complex etiology, aggressive progression, and high mortality rates. Metabolic reprogramming is a hallmark of cancer, and lactate, a key end-product of glycolysis, has emerged as more than just a metabolic waste product. Recent groundbreaking research has unveiled lactate’s role as a signaling m... Read more
Open Access
Volume 1 : Issue 3
Review Article
Ecology
Shamaki Rimamnyang Ayina, Emeka Daniel Oruonye, Joshua, Ma’aku Mark, Benjamin Ezekiel Bwadi
Dec 22, 2025
Article Views: 436
Download: 333
Pages: 192-203
DOI Pending
Abstract: Socio-economic Impacts of Ecosystem Service Degradation in Southern Ecological Zone of Taraba State Nigeria, The degradation of ecosystem services poses a critical threat to rural livelihoods and socio-economic stability in resource-dependent regions of sub-Saharan Africa. This study investigates the perceived socio-economic impacts of ecosystem service decline across five Local Government Areas (LGAs); Bali, Gashaka, Sardauna, Takum, and Ussa—in the Southern Ecological Zone of Taraba State, Nigeria. Employing a... Read more