Global Journal of Clinical and Translational Neurology

The Oral-Brain Axis in Alzheimer’s Disease: Mechanisms Linking Periodontitis to Neurodegeneration and Translational Prevention Strategies

Abstract: Alzheimer’s disease (AD) is characterized by extracellular amyloid-β (Aβ) deposition, intracellular tau pathology, neuroinflammation, and progressive neurodegeneration. Increasing evidence suggests that chronic peripheral inflammatory conditions may influence the onset and progression of AD. Periodontitis, a dysbiosis-driven inflammatory disease of the tooth-supporting tissues, has emerged as a potential contributor through systemic immune activation, recurrent bacteremia, and dissemination of microbial virulenc... Read more